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KMID : 1143420200130342514
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Public Health Weekly Report
2020 Volume.13 No. 34 p.2514 ~ p.2522
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Comparison of Close and Casual Contacts with Latent Tuberculosis Infection in High School Tuberculosis Outbreaks, 2013-2017
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Kim Ji-Eun
Kim Young-Man
Park Shin-Young
Han Sun-Mi
Park Yong-Joon
Park Young-Joon
KTEIS
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Abstract
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The diagnosis and treatment of latent tuberculosis infection (LTBI), a state of persistent immune response to stimulation by Mycobacterium tuberculosis antigens with no evidence of clinically manifest active tuberculosis (TB), are essential to reduce the burden of TB worldwide. Close contacts of active TB patients are at high risk of both active TB and LTBI. The risk of infection with TB depend on the infectivity and degree of contact with a TB patient. This study compared the rate of LTBI according to the degree of contact in high school TB outbreaks in Korea. The 2013 to 2017, LTBI tests of students in 44 high schools were analyzed. Of the 46,357 contacts, 43,963 were tested. Eighty seven TB patients were found, and 2,418 were diagnosed with LTBI. Of the 3,223 close contacts, 36 TB patients and 339 individuals with LTBI were diagnosed and 51 additional patients and 2,079 LTBI patients were found among the 40,840 casual contacts.
As a result of contact investigations in high schools, the incidence of additional TB patients and the LTBI rate were found to be high among close contacts, confirming that the management of close contacts is critical in the fight to eradicate TB.
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KEYWORD
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Tuberculosis, Latent tuberculosis infection, Contact investigation, Close contact, High school
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